NEPATA CATERIA'S ANTI-MALARIAL ACTION: IN VIVO EVALUATION OF METHANOLIC LEAF EXTRACT

Abstract

Malaria, an age-old infectious disease, stands as a pervasive contributor to suffering and mortality, particularly afflicting children under 5 years, predominantly in the developing world. With a historical record of causing profound societal and economic impacts, malaria remains a critical global health concern, causing substantial energy loss, debilitation, and economic damage. The gravity of the disease is underscored by its historical toll, with Riscoe et al. (2005) asserting that malaria has claimed the lives of approximately half of all individuals who have ever lived. This vector-borne illness not only affects individuals but reverberates through families and entire societies, disrupting productivity and causing substantial losses in the workforce. The energy depletion, debilitation, and economic and social consequences of malaria surpass those of other human parasitic diseases. In light of its wide-reaching implications, urgent attention is directed towards addressing the challenges associated with anti-malarial drug resistance and the prevalence of counterfeit drugs circulating in Nigerian markets. Considering the pressing need for effective malaria treatment options, this study emphasizes the imperative for novel drugs or drug combinations with refined modes of action. The exploration of innovative therapeutic approaches is paramount to combat the challenges posed by drug resistance and the presence of counterfeit drugs in circulation. The study aims to contribute to the ongoing efforts to enhance malaria treatment strategies, ensuring the development of effective interventions to alleviate the profound impact of this ancient and relentless disease on global health.