INVESTIGATING PUERARIN'S INFLUENCE ON GLUTAMINE SYNTHETASE DURING ACUTE INTRAOCULAR HYPERTENSION IN RAT RETINA
Keywords:
Puerarin, isoflavone, cardiovascular health, vasodilation, myocardial function.Abstract
Puerarin, a prominent isoflavone derived from the root of Pueraria, specifically the leguminous kudzu plant (Radix puerariae), has garnered significant attention for its diverse pharmacological properties. This compound, identified as 4,7-dihydroxy-8-β-D glucose isoflavone, is commonly extracted and purified from dried root extracts of the kudzu plant. Extensive research has demonstrated the multifaceted therapeutic effects of puerarin, particularly in cardiovascular health.
Studies have revealed that puerarin exhibits vasodilatory effects on both coronary and cerebral vascular smooth muscle, leading to a reduction in vascular resistance and myocardial oxygen consumption. Moreover, puerarin has been associated with the improvement of myocardial contractility and microcirculation function, along with the notable ability to inhibit platelet aggregation. These findings underscore the potential of puerarin as a valuable therapeutic agent in the management of cardiovascular disorders.
In clinical practice, puerarin has been effectively utilized for the treatment of various human diseases, including ischemic heart disease and cerebrovascular/retinal conditions. The application of puerarin in ischemic heart disease has shown promising results, contributing to the enhancement of myocardial function and alleviation of vascular complications. Additionally, its efficacy in treating cerebrovascular and retinal diseases further establishes puerarin as a versatile compound with broad-ranging clinical implications.
This comprehensive abstract aims to provide a succinct overview of the pharmacological attributes of puerarin, emphasizing its potential applications in cardiovascular medicine. The vasodilatory, antiplatelet, and microcirculatory effects of puerarin underscore its role in ameliorating various aspects of cardiovascular health. Furthermore, the successful integration of puerarin into clinical practice for the treatment of ischemic heart disease and cerebrovascular/retinal diseases highlights its translational potential and therapeutic significance.
