October - Volume 1, Number 1 (2023)
Safety Profile of Regorafenib in King Abdullah Medical City: A Retrospective Chart Review Study
Hasan Ahmed H Baz Hasan Ahmed, Saeed H. Halawan Saeed, Ibrahim Abdulaziz Abdulaziz
Regorafenib, an oral tyrosine kinase inhibitor and antineoplastic agent, has been shown to be effective in managing advanced cancers. However, its use is associated with a variety of adverse events. This retrospective chart review study was conducted to determine the safety profile of regorafenib in King Abdullah Medical City. Data from all patients who received regorafenib between December 2021 and May 2020 were collected, including patient demographics, diagnosis, regorafenib starting and escalated doses, reported adverse events, and associated management. The study found that hyperbilirubinemia and fatigue were the most commonly reported adverse events, with half of the patients discontinuing the...
Antibacterial potential of crab shell extract on Klebsiella pneumoniae and Proteus mirabilis
Tracy Adole Adole, Barry A. Omogbai Omogbai
This study aimed to evaluate the antibacterial potential of crab shell extract, a by-product of the seafood industry in Nigeria, on Klebsiella pneumoniae and Proteus mirabilis. The antibacterial susceptibility of both bacteria was tested using crab shell extract and compared with commonly used antibiotics. Results demonstrated that only K. pneumoniae was sensitive to the crab shell extract while P. mirabilis was resistant. The highest zone of inhibition for K. pneumoniae was recorded for isolate Kp2 at a concentration of 200μg/ml. Chitin and chitosan, two derivatives from crab shell extract, were also explored for their antibacterial properties. Chitosan, a non-toxic biodegradable...
Public Health Interventions for Preventing Cardiovascular Diseases through Magnesium Supplementation via Drinking Water
J. Gumashta Gumashta, R. Gumashta Gumashta, S. K. Sadawarte Sadawarte
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Several epidemiological studies have shown that areas with harder water have a lower incidence of CVD, indicating that magnesium may be the cardiovascular-protective factor. Magnesium is required for various biochemical reactions and is a structural component of cardiac muscle. The overreliance on processed foods, lack of green leafy vegetables, and softened drinking water can contribute to magnesium deficiency. Magnesium supplementation through fortified drinking water can result in public health interventions to prevent many diseases, particularly CVD. This review provides an overview of the role of magnesium in preventing...
Photocatalytic and Antimicrobial Properties of Titanium Dioxide Micro-particles under UV Irradiation on Escherichia coli Strains
Rajshree Gupta Gupta, Vaibhav Sharma Sharma
This study investigates the antimicrobial properties of Titanium Dioxide (TiO2) micro-particles in suspension under UV irradiation on Escherichia coli strains obtained from soil and sewage samples. The aim of this research is to explore the potential applications of TiO2 as a non-toxic and effective agent to eliminate microorganisms in areas where traditional chemical cleaning agents or biocides have proven to be ineffective. The methodology involved the collection of samples from sewage and soil, isolation of E.coli from the samples, preparation of TiO2, illuminating E.coli under UV light, and performing plate count. The observations showed a significant decrease in the viable...
Optimization of PHA production from waste frying oil by Pseudomonas aeruginosa
Varaprasad Y Varaprasad, Laxminarayana B Laxminarayana
The increasing amount of plastic waste and its negative impact on the environment has led to the development of biodegradable plastics, such as polyhydroxyalkanoates (PHA). PHA is a biodegradable polyester synthesized by bacteria and has garnered attention as a solution to the plastic waste problem. In this study, we aimed to optimize PHA production from waste frying oil using Pseudomonas aeruginosa. We compared the PHA production of P. aeruginosa and Bacillus subtilis, the two screened microorganisms, using different carbon sources including rice bran, paddy husk, pigeon pea waste, sugarcane bagasse, and waste frying oil. Our results showed that P. aeruginosa...