<p>Bone tissue engineering aims to develop strategies to promote bone regeneration in cases of injury or disease. One critical factor for successful bone regeneration is efficient vascularization, as it ensures the supply of essential nutrients to support new bone growth. The intricate relationship between angiogenesis (blood vessel formation) and osteogenesis (bone formation) is crucial for the healing of bone defects. This review summarizes recent research on signaling molecules that play a significant role in promoting angiogenesis within bone tissue engineering. By understanding these signaling pathways, researchers can develop innovative approaches to enhance vascularization and ultimately improve the outcome of bone tissue engineering strategies</p>