- Volume 11, Number 1 (2023)
REACTIVITY REDEFINED: DIVERSE CARBONYLATION STRATEGIES OF PHCU·P(N-BUTYL)3 FOR THE SYNTHESIS OF BENZOPHENONE
Benjamin Sullivan
The carbonylation of alkylcopper reagents, as initially demonstrated by Jeffery Schwartz in 1972, represents a critical synthetic pathway for generating symmetrical ketones through quenching with dilute aqueous acid. While this groundbreaking discovery has been pivotal for the synthesis of symmetrical ketones, it has primarily focused on dialkyl cuprates and alkylcopper complexes of tri-n-butylphosphine. Interestingly, the simple alkylcopper compounds, without the presence of tri-n-butylphosphine, do not exhibit similar reactivity. Remarkably, the scope of this reaction has yet to be explored in the context of arylcopper reagents, a class of compounds that holds immense significance in organic synthesis. Consequently, this study aims...
MAGNETITE MAGIC: INVESTIGATING THE IMPACT OF U. TOMENTOSA LEAF-EXTRACTED NANOPARTICLES ON GREEN PEACH APHID INFESTATION
Salma Nour Abdallah
Magnetite (Fe3O4) nanoparticles have gained significant attention due to their diverse applications in various fields, including biomedicine, agriculture, and diagnostics. The tunable properties of these nanoparticles make them suitable for targeted drug delivery, cancer diagnostics, magnetic resonance imaging, catalysts, pharmaceuticals, and more. Several synthesis methods have been developed to prepare magnetite nanoparticles, but many of these methods involve purification steps, hazardous by-products, and high-temperature conditions. In response to these limitations, researchers have turned to environmentally friendly and cost-effective "green" synthesis routes using plant extracts. In this study, we explored the synthesis of magnetite nanoparticles (Fe3O4NPs) through a green approach, utilizing...
CHEMICAL REACTIVITY EXPLORED: KINETIC ANALYSIS OF IMINES AND HYDRAZONES HYDROLYSIS IN A PHYSIOLOGICALLY RELEVANT ENVIRONMENT
Ahmed Saad Al-Abdullah
The addition of nucleophilic species to carbonyl groups, leading to the formation of tetrahedral intermediates that subsequently undergo an addition-elimination mechanism, is a fundamental chemical process. Such reactions are particularly significant in the context of primary amino groups and aldehydes, as they serve as model reactions for various biological processes. This study delves into the kinetic aspects of the hydrolysis of imines, which are intermediates formed during these reactions, with a focus on their behavior in aqueous acidic environments. The hydrolysis of imines, especially those derived from primary amino groups and aldehydes, is a complex process with several potential reaction...