"PHARMACISTS' PERSPECTIVES ON CHRONOTHERAPY IN NORTHWEST NIGERIA: A COMPREHENSIVE STUDY"

Abstract

Circadian rhythms play a pivotal role in modulating the pharmacological effects of drugs, influencing their efficacy and safety. Administering medications at specific times of the day has emerged as a critical factor in patient care and management. This systematic review explores the impact of circadian rhythms on drug therapy, aiming to enhance therapeutic outcomes. Multiple studies have demonstrated the potential for improved drug efficacy when administered at particular times of the day. Given that both pharmacokinetics and pharmacodynamics are influenced by biological rhythms, considering these variations is essential before medication administration.

Chronotherapy, an approach to optimize safe and effective pharmacotherapy by aligning drug administration with the body's biological rhythms, is gaining prominence. Circadian rhythms have been implicated in a wide range of human diseases, including insomnia, sleep disorders, jetlag, cardiovascular diseases, hypertension, metabolic disorders, neurological and psychiatric conditions, and hormone-dependent cancers. Understanding the intricate interplay between circadian rhythms and drug effects is essential for tailoring treatment strategies and improving patient outcomes.